Rabies PEP Management Summary with ID Preference + Tetanus Immunization After Wounds (หมากัด แมวข่วน รถล้ม แผลถลอก)

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💉 Rabies PEP Management Summary with ID Preference

Exposure CategoryImmune StatusVaccination HistoryManagementVaccine ScheduleRIG Required?
CAT 1AllAny❌ No treatment needed–❌ No
CAT 2NormalVaccinated <6 monthsBooster✅ Day 0 only (1 dose) • IM or ID 2-site❌ No
CAT 2NormalVaccinated >6 monthsBooster✅ Day 0, 3 • IM or ID 2-site or ID 4-site Day 0❌ No
CAT 2NormalNever vaccinatedFull vaccine✅ ID 2-site Days 0, 3, 7, 28 or IM Days 0, 3, 7, 14, 28❌ No
CAT 2Immuno compromisedAnyFull vaccine + RIG❗ IM only: Days 0, 3, 7, 14, 28✅ Yes
CAT 3NormalVaccinated <6 monthsBooster + RIG✅ Day 0 only (1 dose) • IM or ID 2-site✅ Yes
CAT 3NormalVaccinated >6 monthsBooster + RIG✅ Day 0, 3 • IM or ID 2-site or ID 4-site Day 0✅ Yes
CAT 3NormalNever vaccinatedFull vaccine + RIG✅ ID 2-site Days 0, 3, 7, 28 or IM Days 0, 3, 7, 14, 28✅ Yes
CAT 3Immuno compromisedAnyFull vaccine + RIG❗ IM only: Days 0, 3, 7, 14, 28✅ Yes

💉 Vaccine Administration Details

🧪 Intradermal (ID) Regimens

  • Dose: 0.1 mL per injection site
  • Sites:
    • 2-site: One injection in each deltoid
    • 4-site: Both deltoids + both anterior thighs or scapulae (only Day 0)

💉 Intramuscular (IM) Regimens

  • Dose: 0.5–1.0 mL depending on brand
  • Site: Deltoid (or anterolateral thigh for infants)

⚠️ Do NOT mix ID and IM regimens during the course — EXCEPTION: if vaccine shortage on Day 3.

🧪 Rabies Immune Globulin (RIG)

TypeDoseAdministration
ERIG (Equine)40 IU/kgInfiltrate around the wound as much as anatomically feasible
HRIG (Human)20 IU/kgSame as above; dilute for mucosal contact (1:10 with NSS if to eye/oral mucosa)

❗ Do not inject remaining RIG elsewhere (e.g., gluteus)✅ Administer only once, within 7 days of first vaccine dose


💉 Tetanus Immunization After Wounds

Ready-to-Use Clinical & Exam Sheet

Step 1: Identify the wound

  • Clean wound = clean, minor, superficial
  • Dirty wound = contaminated, puncture, soil/feces/saliva, devitalized tissue, burns, crush injuries, bites

🧾 Tetanus Immunization Table (COMPLETE)

SituationAction
No or unknown tetanus history🧷 Start full primary course (3 doses)  
• Dose 1: day 0
• Dose 2: ≥4 weeks after dose 1
• Dose 3: 6–12 months after dose 2
➕ Add TIG if dirty wound
<3 doses received (incomplete series)🧷 Complete the remaining doses  
• Continue where left off
• Do NOT restart series  
➕ Add TIG if dirty wound
≥3 doses, clean wound, last dose ≥10 years💉 Booster dose (Td or Tdap) x1
≥3 doses, clean wound, last dose <10 years✅ No booster needed
≥3 doses, dirty wound, last dose >5 years💉 Booster dose (Td or Tdap) x1
≥3 doses, dirty wound, last dose ≤5 years✅ No booster needed

✅ This row completes the table and avoids confusion in exams and practice.

💉 Vaccine Details

  • Vaccine: Td or Tdap
  • Dose: 0.5 mL IM x1
  • Tdap preferred if patient has never received Tdap before

🧪 TIG (Tetanus Immune Globulin) — Quick Rules

TIG is used ONLY if BOTH are present:

  1. Dirty / high-risk wound
  2. Inadequate (<3 doses) OR unknown vaccination history

❌ Never needed if:

  • Clean wound
  • AND ≥3 documented doses

TIG Dose

  • 250 IU IM once
  • May increase dose in heavily contaminated wounds
  • Administer at a separate site from vaccine

📌 High-Yield Exam Memory Box

  • “Full course” = 3 doses → builds immunity
  • “Booster” = 1 dose → maintains immunity
  • Dirty wound rules:
    • ≥5 years → booster
    • <5 years → no booster
  • Clean wound rules:
    • ≥10 years → booster
    • <10 years → no booster
  • Never restart the series
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