
Uncertainty and Sensitivity Analysis in Health Economic Evaluation: Principles, Tools, and Application
Introduction In health economics, decisions are rarely made under conditions of perfect certainty. Clinical outcomes, cost estimates, and...

Decision Trees and Markov Models in Health Economic Evaluation: Principles, Construction, and Applications
Introduction Healthcare decisions—whether at the bedside or in national policy—often require a systematic way to weigh options under...

The Role of Health Economic Evaluation in National Drug Selection and Decision-Making
Introduction Health systems worldwide confront an increasingly complex matrix of clinical innovation, economic pressure, and population...

PRISMA 2020: A Comprehensive Guide to Transparent and Rigorous Reporting of Systematic Reviews
Introduction Systematic reviews are a cornerstone of evidence-based medicine. They collate findings from multiple studies to address...

AMSTAR 2: Methodological Framework for Appraising the Quality of Systematic Reviews
Introduction Systematic reviews synthesize empirical evidence to guide clinical and policy decisions. However, the validity of their...

Common Parasites & First-Line Treatments
🦠 Common Parasites & First-Line Treatments Disease Causative Agent Drug of Choice Dose & Notes Strongyloidiasis Strongyloides...

How to Critically Appraise a Systematic Review (SR) and Meta-Analysis (MA): Using AMSTAR 2, GRADE, and CINeMA
Introduction Systematic reviews and meta-analyses are central to evidence-based clinical decision-making. They synthesize findings from...

Network Meta-Analysis Explained: Comparing Multiple Treatments in One Framework
Introduction When multiple therapeutic options exist for a single clinical condition, traditional evidence synthesis methods may fall...

GRADE Framework: A Systematic Approach to Rating the Quality of Evidence
Introduction In clinical research and guideline development, making well-informed decisions depends not only on what evidence exists but...

Designing and Implementing a Data Extraction Form for Systematic Reviews
Introduction Systematic reviews synthesize evidence across studies to address a focused clinical or research question. However, their...

How to Systematically Screen Records and Full Texts in Evidence Synthesis
Introduction In systematic reviews and meta-analyses, identifying relevant studies is not a one-step act of database searching. It is a...

How to Perform a Systematic Search in Clinical Research
Introduction A systematic search is the foundation of any high-quality systematic review or meta-analysis. Unlike narrative reviews that...

Evaluating the Feasibility of Systematic Review and Meta-Analysis Questions
Introduction Before launching a systematic review or meta-analysis, researchers must rigorously assess whether the review question is...

Systematic Reviews and Meta-Analyses: Foundations of Evidence Synthesis
Introduction Clinical decision-making demands a foundation of rigorous evidence. In an era flooded with individual studies, often with...

Common Cold vs. Viral Pharyngitis: Clinical Comparison & Diagnostic Pearls
Table: Common Cold vs. Viral Pharyngitis Feature Common Cold (URI) Viral Pharyngitis Etiology Rhinovirus, coronavirus, RSV, adenovirus...

Common Cold & Upper Respiratory Tract Infection (URI): Symptoms, Diagnosis, Red Flags, Treatment Guide, and When to Use Antibiotics
📌 1. Clinical Presentation Symptom Typical Findings Fever May or may not be present; usually low-grade (<38.3°C) Cough Dry or productive...

Emulating the Target Trial: A Framework of Strengthening Causal Inference in Observational Research
Introduction In clinical research, particularly therapeutic studies, randomized controlled trials (RCTs) remain the gold standard for...

Sequential Designs in Clinical Trials: Rationale, Types, and Implementation
Introduction Traditional randomized controlled trials (RCTs) typically wait until full recruitment and data collection are complete...

Interim Analyses in Clinical Trials: Purpose, Principles, and Practice
Introduction Randomized controlled trials (RCTs) are foundational to evaluating therapeutic efficacy and safety. Traditionally, these...

Designing and Conducting Cluster Randomized Trials: A Comprehensive Guide
Introduction In the evolution of clinical trial methodology, traditional individual-level randomization, while foundational, is sometimes...

Embracing Complexity in Clinical Trials: A Methodological Guide to Design and Interpretation
Introduction Modern clinical research is increasingly challenged by the complexity of real-world settings. No longer limited to one...

Designing Trials Around What Patients Want: The Science of Patient Preference Trials
Introduction Traditional randomized controlled trials (RCTs) are a cornerstone of clinical research, providing high internal validity by...

Rethinking Consent in Clinical Trials: Zelen's Design
Introduction Randomized controlled trials (RCTs) are the gold standard in evaluating therapeutic interventions. Yet, their implementation...

Pragmatic Clinical Trials: Real-World Impact & the PRECIS-2 Framework
Introduction In contemporary clinical research, the relevance of a study's results to real-world healthcare settings is paramount. This...





