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The Role of Vitamin K and Calcium in Coagulation Cascade

Updated: Jan 23

Ca 2 9 10 11/ II, IX, X, and XI. Vitamin K 2 7 9 10/ II, VII, IX, and X.



Understanding Calcium and Vitamin K in the Coagulation Cascade

Calcium's Role in Coagulation

  • Key Clotting Factors: Calcium is vital for the function of clotting Factors II, IX, X, and XI.

  • Activation Process: It aids in activating these factors, crucial for the coagulation cascade's progression.

  • Complex Formation: Calcium ions facilitate the formation of complexes between clotting factors and phospholipid surfaces on platelets, enabling the sequential activation of the coagulation cascade.

  • Factor IV: Given its importance, calcium is sometimes referred to as Factor IV. ref: https://eclinpath.com/hemostasis/physiology/secondary-hemostasis/coagulation-cascade-new-model-3/


Vitamin K's Role in Coagulation


Clinical Implications

  • Anticoagulant Therapy Monitoring: Monitoring levels and activity of these specific clotting factors is crucial in patients on anticoagulant therapy, particularly with vitamin K antagonists.

  • Dietary Importance: Adequate dietary intake of vitamin K and calcium is important for the proper functioning of the coagulation system.

Summary: Calcium and vitamin K are essential for coagulation, with calcium involved in the function of Factors II, IX, X, and XI, and vitamin K necessary for the synthesis and activation of Factors II, VII, IX, and X. Their roles are key to understanding coagulation mechanisms and managing related clinical conditions.

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