PRISMA 2020: A Comprehensive Guide to Transparent and Rigorous Reporting of Systematic Reviews

Mayta
2 days ago
4 min read

Introduction

Systematic reviews are a cornerstone of evidence-based medicine. They collate findings from multiple studies to address well-defined research questions, informing clinical guidelines, health policy, and future research. However, their utility hinges not only on methodological rigor but also on how transparently the methods and findings are reported. Incomplete or ambiguous reporting can hinder replication, mislead stakeholders, and erode trust.

To address these challenges, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 update provides a modernized, detailed checklist to guide authors in crafting transparent, complete, and interpretable systematic review reports. It supersedes PRISMA 2009, incorporating advances in methods, technology, and reporting expectations.

Core Principles and Scope

PRISMA 2020 is a reporting guideline, not a methodological quality assessment tool. Its primary purpose is to ensure that reviews—regardless of design or topic—present what was done, why it was done, and what was found, with enough clarity for users to evaluate, replicate, and trust the review.

It applies to:

Reviews of interventions (health, social, or educational)
Reviews of etiology, prevalence, or prognosis
Reviews with or without meta-analysis
Mixed-methods systematic reviews
Original, updated, and living systematic reviews

Extensions exist for specific formats (e.g., network meta-analyses, individual patient data, scoping reviews), which should be used in conjunction with the core PRISMA 2020 guideline.

PRISMA 2020 Structure: The 27-Item Framework

The checklist is grouped into seven sections:

Title
Abstract
Introduction
Methods
Results
Discussion
Other Information

Each item includes essential reporting elements and, where relevant, supplementary elements that enhance completeness. Below is a structured walk-through of the conceptual flow.

Section-by-Section Breakdown

1. Title and Abstract

Title: Clearly state the work is a systematic review. Optional additions include review type, target population, intervention, or study design.
Abstract: Follow the 12-item PRISMA Abstracts checklist, covering objectives, methods, main outcomes, synthesis type, and key limitations.

2. Introduction

Rationale: Contextualize the review within existing knowledge, outlining gaps or conflicts it seeks to resolve.
Objectives: Formulate a clear research question using frameworks like PICO or alternatives suitable to the review’s aim.

3. Methods

A methodologically transparent review must answer:

What was eligible?Specify inclusion/exclusion criteria for studies and reports (design, population, outcomes, setting, date, language).
Where and how was information retrieved?List all databases, registries, websites, and contacts searched. Provide full search strategies—including filters and dates—for all sources.
How were studies selected?Explain the screening process, detailing how many reviewers participated, their independence, and any automation tools used.
What data were collected and how?Describe the data extraction process, reviewer roles, contact with authors, and use of software or automation.
What were the outcomes and variables of interest?Define each outcome domain, time point, and other variables (e.g., demographics, funding). Clarify how multiple results were handled.
How was risk of bias assessed?Specify the tool used (e.g., RoB 2, ROBINS-I), its components, how judgments were made, and how many reviewers were involved.
What effect measures were used?Report the statistical metrics (e.g., risk ratio, odds ratio, mean difference) used for each outcome and their interpretative thresholds.
How were results synthesized?PRISMA subdivides synthesis into six sub-items:
- Grouping of studies (13a)
- Data preparation methods (13b)
- Tabular/graphical displays (13c)
- Statistical models and heterogeneity handling (13d)
- Exploration of heterogeneity (13e)
- Sensitivity analyses (13f)
How were reporting biases and certainty handled?Describe how publication bias and selective reporting were assessed (e.g., funnel plots, Egger's test) and how certainty was judged (e.g., GRADE).

4. Results

This section mirrors the methods and demands exhaustive transparency:

Selection process: Provide counts of identified, screened, and excluded records. Use a PRISMA 2020 flow diagram.
Included studies: Describe study characteristics, risk of bias, and outcomes.
Synthesis: Present summary estimates, heterogeneity metrics, subgroup/sensitivity results, and certainty ratings.

5. Discussion

Interpretation: Situate findings in context.
Limitations: Address both evidence and methodological weaknesses.
Implications: Suggest implications for practice, policy, and future research.

6. Other Information

Registration and Protocol: Provide registration number and protocol access. Explain protocol deviations.
Funding and Competing Interests: Declare all support and potential conflicts.
Availability of Data and Materials: Disclose the accessibility of data, extraction forms, code, and other materials.

Innovations in PRISMA 2020

PRISMA 2020 is not merely a cosmetic update. It reflects deeper shifts:

Broader scope: Non-health and mixed-methods reviews are now explicitly included.
Meta-analysis optional: Transparency matters even without synthesis.
Emphasis on automation: New guidance for machine-assisted screening and data extraction.
Focus on certainty: Recognizes that bias ≠ imprecision ≠ inconsistency.
Tools and templates: Open-access checklists, flow diagrams, and web apps are available to aid compliance.

Conclusion

PRISMA 2020 redefines reporting in systematic reviews, urging authors to make every step of their process visible and verifiable. For PhD researchers, its framework reinforces methodological discipline, fosters reproducibility, and enhances scientific integrity.

Mastery of PRISMA is not merely about ticking boxes. It’s about embodying the ethic of evidence clarity—a core competency in clinical epidemiology.

Key Takeaways

PRISMA 2020 consists of a 27-item checklist spanning seven sections.
It demands clarity on inclusion criteria, synthesis logic, and bias handling.
Embraces automation, mixed methods, and non-interventional reviews.
Reinforces transparent, reproducible, and verifiable scientific practice.