What Is Integrated Discrimination Improvement (IDI)? A Clear Guide with Example
Clinical Epidemiology ResearchUniqcret doctor knowledgesMethodology and Research DesignDiagnosis [Methodology]
🧪 What Is IDI?
While Net Reclassification Improvement (NRI) focuses on category shifts, IDI measures how much the new model improves average predicted probabilities for cases and non-cases across all thresholds—without relying on arbitrary cutoffs.
Key Idea:
IDI tells you how much better the new model separates diseased from non-diseased individuals.
📐 The IDI Formula
🧪 Conceptual Analogy
Think of a scatter plot of predicted probabilities:
- Good models spread cases (D=1) toward high predicted probabilities
- And spread non-cases (D=0) toward low predicted probabilities
So:
- IDI = "How much farther apart are the two clouds (D=1 vs D=0) in the new model compared to the old one?"
🔢 An Example in Numbers
You are comparing two diagnostic models for early liver fibrosis:
- Model A: uses age, AST/ALT ratio
- Model A+B: adds a novel serum fibrosis biomarker
Suppose we calculate:
| Mean Predicted Probability (Cases, D=1) | Mean Predicted Probability (Non-Cases, D=0) | |
| Model A | 0.42 | 0.21 |
| Model A+B | 0.58 | 0.18 |
💡 When to Use IDI?
Use IDI when:
- You're comparing models, not just tests
- You want to avoid arbitrary cutoff thresholds
- You need a continuous, overall measure of improvement
- You want a complement to AUC, NRI, and calibration metrics