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How to Management the Notify Abdominal Pain, Bloating, and Abdominal Discomfort in an Inpatient [IPD] Setting Using Domperidone, Onsia, Losec, Buscopan, Norfloxacin, Plasil, Senokot, and Lactulose

Writer's picture: MaytaMayta

Updated: Dec 16, 2024

A table with the ready-to-use medication orders based on the Management of the Notify such Abdominal Pain:

Medication

Dose and Administration

Domperidone (Motilium)

10 mg 1x3 PO AC

Ondansetron (Onsia)

8 mg IV slowly push PRN, q 8 hr as needed

Losec (Omeprazole)

40 mg IV once daily

Buscopan (Hyoscine)

20 mg IV PRN, q 8 hr as needed

Norfloxacin

400 mg 1x2 PO PC (after meals)

Plasil (Metoclopramide)

10 mg IV PRN, q 8 hr as needed

Senokot (Senna)

2 tablets PO HS (at bedtime)

Lactulose

30 ml PO HS or OD; discontinue if diarrhea occurs ≥ 3 times


 

Introduction

Bloating and abdominal discomfort are common complaints in clinical practice, often presenting as a sensation of fullness, tightness, or swelling in the abdomen. These symptoms can arise from various underlying causes, including gastrointestinal disorders, infections, motility issues, and functional disturbances. In the inpatient (IPD) setting, a systematic approach is crucial for effective management, particularly when symptoms persist or worsen. This article outlines a structured management plan, including pharmacological and supportive measures, tailored for patients presenting with bloating and abdominal discomfort in the inpatient setting.

 

Initial Assessment and DiagnosisComprehensive History and Physical Examination

  • Obtain a detailed history focusing on the onset, duration, and nature of symptoms (e.g., constant vs. intermittent bloating, association with meals, presence of constipation, diarrhea, or nausea).

  • Assess any history of gastrointestinal disorders (e.g., GERD, IBS, peptic ulcers), recent infections, medication use, or dietary habits.

  • Perform a thorough physical examination to identify any signs of tenderness, guarding, distension, or organomegaly.


 

Diagnostic Investigations

  • Laboratory Tests: CBC, electrolytes, liver function tests, renal function tests, and amylase/lipase levels to rule out metabolic or systemic causes.

  • Imaging Studies: Abdominal ultrasound or CT scan may be warranted if there is suspicion of obstruction, intra-abdominal mass, or significant fluid accumulation.

  • Stool Analysis: For patients with diarrhea, stool tests for pathogens (bacteria, parasites) and inflammatory markers (calprotectin) may be helpful.


 

Pharmacological ManagementIn managing bloating and abdominal discomfort, medications should be selected based on the underlying cause and predominant symptom. Below is a step-by-step guide for a comprehensive treatment plan:

  1. Acid-Reducing Agent

    • Losec (Omeprazole) 40 mg IV once daily


      Indication: Proton pump inhibitor (PPI) that decreases gastric acid production, helping in cases of GERD, peptic ulcers, or acid-related dyspepsia contributing to bloating.


      Rationale: Effective in managing acid-related conditions.


      Order: 40 mg IV once daily.

  2. Antispasmodic

    • Buscopan (Hyoscine) 20 mg IV PRN, q 8 hr


      Indication: Relieves smooth muscle spasms and cramping in the GI tract, beneficial in IBS or functional dyspepsia.


      Rationale: Alleviates cramping that may worsen bloating.


      Order: 20 mg IV PRN, up to every 8 hours as needed.

  3. Antibiotic (If Infection is Suspected)

    • Norfloxacin 400 mg PO PC, BID


      Indication: Used for bacterial gastroenteritis or other GI infections presenting with bloating and abdominal discomfort.


      Rationale: Treats underlying infection when confirmed or highly suspected.


      Order: 400 mg PO PC, twice daily.

  4. Prokinetics and Antiemetics

    • Plasil (Metoclopramide) 10 mg IV PRN, q 8 hr Indication: Enhances gastric emptying, reduces nausea, and alleviates bloating due to delayed gastric emptying. Rationale: Promotes forward propulsion of gastric contents, easing discomfort. Order: 10 mg IV PRN, up to every 8 hours.

    • Domperidone 10 mg 1x3 PO ac Indication: A peripheral dopamine D2 receptor antagonist that improves gastric motility and helps with nausea and bloating, similar to metoclopramide but with fewer central nervous system side effects. Rationale: Enhances gastric emptying and reduces discomfort related to slow GI transit. Order: Typically 10 mg PO TID (approximately 15–30 minutes before meals). Adjust according to response and local guidelines.

    • Onsia 4–8 mg IV or PO up to three times daily as needed. (Brand name and generic composition may vary by region; verify availability and indication) Indication & Rationale: If Onsia is an antiemetic or prokinetic agent as per regional medical formulary, it can be employed similarly to other prokinetics or antiemetics to relieve bloating and nausea. Order: Depending on the specific generic drug, recommended dosing should follow local prescribing information. Confirm the active ingredient and indication before use.

  5. Laxatives (For Constipation-Induced Bloating)

    • Senokot (Senna) 7.5 mg, 2 tablets PO HS (at bedtime) Indication: Stimulates bowel movements, helpful if constipation contributes to bloating. Rationale: Reduces bloating by preventing stool accumulation and encouraging regular bowel movements.Order: 2 tablets PO at bedtime.

    • Lactulose 30 ml PO HS or OD, discontinue if diarrhea occurs ≥ 3 times Indication: Osmotic laxative for managing chronic constipation. Rationale: Softens stools and improves stool frequency, reducing bloating caused by slow transit. Order: 30 ml PO at bedtime or once daily, discontinue if diarrhea occurs 3 or more times.


 

Supportive MeasuresDietary Modifications

  • Low FODMAP Diet: Reduce intake of fermentable carbohydrates that can exacerbate bloating.

  • Small, Frequent Meals: Prevent over-distension by eating smaller portions throughout the day.


 

Lifestyle Recommendations

  • Encourage Ambulation: Light physical activity can promote gut motility and relieve bloating.

  • Avoid Carbonated Beverages: Prevent additional gas buildup in the GI tract.

 

Monitoring and Follow-Up

  • Vital Signs and Fluid Balance: Regular monitoring is essential, especially if diarrhea or vomiting occurs.

  • Reassessment: Reevaluate symptoms regularly and adjust the treatment plan accordingly. Consider further investigations if there is no improvement or new symptoms arise.

 

Conclusion Management of bloating and abdominal discomfort in an inpatient setting requires a tailored, multifaceted approach. By incorporating acid suppression, antispasmodics, antibiotics (when indicated), prokinetics (such as metoclopramide or domperidone), and possibly emerging options like Onsia (pending clarification on its generic composition), alongside laxatives for constipation-related issues, clinicians can address various underlying mechanisms. Combined with dietary modifications, lifestyle interventions, and careful monitoring, this comprehensive strategy aims to alleviate symptoms, enhance patient comfort, and improve outcomes.

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